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Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects. 4.3 Contraindications, hypersensitivity to the active substance or to any of the excipients listed in section nsistent with its known effects on the nitric oxide/cyclic guanosine monophosphate (cGMP) pathway (see section.1 sildenafil was shown to potentiate the hypotensive effects of nitrates, and its co-administration. It is supplied by Pfizer.S.
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